Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAnimalsPyrimidinesMiceInbred C57BLMale
KN21, a direct AMPK activator, alleviates hepatic steatosis and fibrosis by modulating long-chain TAG and pyrimidine metabolism in a MASH mouse model.
Jueun Lee, Seojeong Kim, Yeajin Ju, Minjung Seo, Hyeri Kim, Jae-Ho Shin, Younghwa Na, Youngjoo Kwon, Geum-Sook Hwang
Published: 202510.1016/j.biopha.2025.118798
Abstract
Metabolic dysfunction-associated steatohepatitis (MASH) is a severe form of metabolic dysfunction-associated steatotic liver disease (MASLD) that is characterized by hepatic steatosis, inflammation, and fibrosis and can progress to cirrhosis and hepa…
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