Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAnimalsHumansCarcinomaNon-Small-Cell LungLung Neoplasms
Targeting the polyol pathway in NSCLC: Trans-(±)-kusunokinin demonstrates anti-migratory and survival benefits in in vitro and in vivo models.
Tanotnon Tanawattanasuntorn, Paradesi Naidu Gollavilli, Adriana Martinez Turtos, Mohammad Aarif Siddiqui, Vignesh Ramesh, Tienthong Thongpanchang, Khotchawan Bangpanwimon, Adisak Noonai, Paolo Ceppi, Potchanapond Graidist
Published: 202510.1016/j.biopha.2025.118795
Abstract
Trans-(±)-kusunokinin (KU), a potential anticancer agent, has been reported as an AKR1B1 inhibitor, a key enzyme in the polyol pathway that converts glucose to sorbitol and subsequently to fructose via sorbitol dehydrogenase (SORD). This pathway cont…
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