Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieHumansSaponinsBreast NeoplasmsFemaleAnimals
Triterpenoid saponins from Ilex latifolia inhibit breast cancer growth by disrupting the SREBP1/FASN-mediated lipid metabolic pathway.
Fangfang Wang, Mingjie Wang, Zihan Shi, Yongchen Wu, Cunqin Wang, Hongting Wang
Published: 202510.1016/j.biopha.2025.118793
Abstract
Dysregulated lipid metabolism is a hallmark of breast cancer progression, with the SREBP-1/FASN axis serving as a key driver of tumor growth and survival. Natural products offer a valuable reservoir of metabolic modulators, yet their mechanisms and t…
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