Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieMethicillin-Resistant Staphylococcus aureusAnimalsAnti-Bacterial AgentsCaenorhabditis elegansAminoglycosides
Repurposed membrane-targeting RS17053 eradicates MRSA persisters and enhances aminoglycoside killing.
Seongeun Baek, Guijin Zou, Nakyung Lee, Jisoo Kang, Jae-Seok Kim, Wonhyo Seo, Huajian Gao, Wooseong Kim
Published: 202510.1016/j.biopha.2025.118763
Abstract
The rapid rise of methicillin-resistant Staphylococcus aureus (MRSA) and its ability to form antibiotic-tolerant persisters pose a major challenge to antimicrobial therapy. These metabolically dormant cells survive antibiotic exposure without genetic…
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