Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieNLR FamilyPyrin Domain-Containing 3 ProteinPPAR gammaAnimalsFibrosis
Bixin prevents tubulointerstitial fibrosis in hyperuricemic nephropathy via promoting PPARγ-NLRP3 interaction.
Yun Cao, Jie Deng, Mingying Lin, Yan Su, Ying Zhang, Maowei Xie, Daofa Zhang, Hui Han, Yanni Wang, Xiangdong Yang, Yizhi Chen, Jiali Wei
Published: 202510.1016/j.biopha.2025.118745
Abstract
Hyperuricemic nephropathy (HN), characterized by severe inflammation-induced tubulointerstitial fibrosis (TIF), has emerged as a common subtype of chronic kidney disease. Bixin, a carotenoid extracted from the seeds of Bixa orellana, recently garnere…
Preview only. Read the full abstract at the source