Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAnimalsGlucocorticoidsSirolimusIntestinal MucosaMice
Rapamycin and parenteral administration attenuate the harmful effects of glucocorticoids on the intestinal barrier function.
Diego Ceacero-Heras, Guillermo Ruiz-Henares, Juan José Enguix-Huete, Mireia Tena-Garitaonaindia, Ángela Jiménez-Ortas, Alba Seguí-Pérez, Olga Martínez-Augustin, Fermín Sánchez de Medina
Published: 202510.1016/j.biopha.2025.118721
Abstract
Glucocorticoids are important anti-inflammatory and immunosuppressant agents. They have weakening actions on intestinal barrier function, including epithelial antiproliferative and mucus antisecretory effects, which may limit their clinical benefit.…
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