Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieLeukemiaMyeloidAcuteAnimalsHumans
Targeting serine metabolism vulnerability in omipalisib-resistant acute myeloid leukemia with phosphoglycerate dehydrogenase inhibitors.
Chi-Yang Tseng, Yu-Hsuan Fu, Da-Liang Ou, Hsin-An Hou, Hsiung-Fei Chien, Liang-In Lin
Published: 202510.1016/j.biopha.2025.118689
Abstract
Acute myeloid leukemia (AML) is the most common acute leukemia that primarily affects older adults. Dysregulated PI3K/AKT/mTOR signaling pathway is a common abnormality in AML. Our previous study demonstrated the excellent cytotoxicity of dual PI3K/m…
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