Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAnimalsNLR FamilyPyrin Domain-Containing 3 ProteinAlzheimer DiseaseReceptors
GPR40 agonist ameliorates neurodegeneration by regulating mitochondria dysfunction and NLRP3 inflammasome in Alzheimer's disease animal models.
Tae-Young Ha, Yeji Kim, Seung Min Lim, Yongjae Hong, Keun-A Chang
Published: 202510.1016/j.biopha.2025.118678
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by mitochondrial dysfunction and chronic neuroinflammation. G-protein coupled receptor 40 (GPR40), primarily known for its role in metabolic regulation, has recently e…
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