Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapiePlasmodium falciparumMalaria VaccinesHumansSporozoitesAdjuvants
A Trojan horse: Chemical boosting of Plasmodium falciparum whole sporozoite vaccine immunogenicity.
Chanel Milène Naar, Roos van Schuijlenburg, Maarten van Meerbeek, Luís Almeida, Fijs W B van Leeuwen, Meta Roestenberg
Published: 202510.1016/j.biopha.2025.118666
Abstract
In non-endemic healthy adults, late-arresting whole sporozoite vaccines have demonstrated a high protective efficacy. To further increase the vaccine potency, we explored options to boost immunogenicity by chemically augmenting SPZ with adjuvants. Ke…
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