Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAnimalsMaleMonoacylglycerol LipasesFemaleMice
MCH11, a new monoacylglycerol lipase inhibitor, reduces ethanol consumption and motivation to drink in mice, with sex-dependent differences.
Abraham B Torregrosa, María S García-Gutiérrez, Daniela Navarro, Francisco Navarrete, Jorge Manzanares
Published: 202510.1016/j.biopha.2025.118662
Abstract
This study examined the effects of the new monoacylglycerol lipase (MAGL) inhibitor, MCH11, on ethanol consumption and motivation in male and female C57BL/6 J mice. First, we evaluated plasma concentrations of MCH11 at different doses (10, 20, 40 mg/…
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