Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAnimalsKetamineClozapineGlutamate DecarboxylaseGlutamic Acid
Effects of JNJ-46356479 and clozapine on VGLUT1 and GAD65/67 brain levels and expression of genes related to glutamate and GABA in mice postnatally exposed to ketamine.
Albert Martínez-Pinteño, David Olivares-Berjaga, Natalia Rodríguez, Juan-Ignacio Mena, Lucia Prohens, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó
Published: 202510.1016/j.biopha.2025.118639
Abstract
Schizophrenia (SZ) is a complex mental disorder influenced by genetic, environmental, and neurobiological factors, with current treatments ineffective for negative symptoms and cognitive deficits. The glutamatergic hypothesis of SZ highlights the N-m…
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