Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAnimalsT-LymphocytesRegulatoryObesityADAM17 Protein
Myeloid ADAM17 induces ST2+ T regulatory cells that limit obesity-induced metabolic inflammation through changes in both membrane and soluble TNF.
Joseph C Lownik, Matthew P Zellner, Jared Farrar, Anuj Tharakan, Francesco S Celi, Daniel H Conrad, Rebecca K Martin
Published: 202510.1016/j.biopha.2025.118627
Abstract
Obesity is a detrimental disease that affects almost all physiological functions of the person that is afflicted. Secreted TNF alpha (sTNF) levels are directly correlated in obesity with weight gain and morbidity, as well as metabolic dysregulation.1…
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