Bioorganic chemistry
Synthesis and mechanistic investigation of N-Alkoxybenzamide derivatives as EGFR inhibitors.
Ting Yang, Wenqiang Zhu, Jiaxue Yang, Fan Zhou, Longjia Yan, Li Liu, Yi Le
Published: 202610.1016/j.bioorg.2026.109530
Abstract
In this study, a series of novel compounds with potent inhibitory activity against EGFRL858R/T790M and EGFRL858R/T790M/C797S were designed and synthesized by employing a fragment combination strategy, integrating the aminopyrimidine fragment with the…
Preview only. Read the full abstract at the source