Bioorganic chemistry
(Z)-4-(substituted benzylidene)-2-phenyl-1H-imidazol-5(4H)-ones are sensitive to tyrosinases of different origins: In vitro and in vivo insights.
Hee Jin Jung, Hyeon Seo Park, Yeonsoo Jeong, Hyejin Kang, Minchang Kim, Hyunju Lee, Hyunhee Ju, Hae Young Chung, Yujin Park, Hyung Ryong Moon
Published: 202610.1016/j.bioorg.2026.109514
Abstract
We used Staudinger azide reduction and Knoevenagel condensation reactions to synthesize 13 different (Z)-4-(substituted benzylidene)-2-phenyl-1H-imidazol-5(4H)-one (BPIO) analogs (1-13) that hybridize a β-phenyl-α,β-unsaturated carbonyl scaffold with…
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