Bioorganic chemistry
2-Aminothiophene and 2-aminothiazole scaffolds as potent antimicrobial agents: Design, synthesis, biological evaluation, and computational insights.
Munugala Chandrakanth, Jyothi Kumari, Paramita Pakhira, Dharmarajan Sriram, Siddhardha Busi, Sampathkumar Ranganathan, Chandni Kumari, Sonam Bisla, Mukesh Pasupuleti, Ramesh Gondru, Jesu Arockiaraj, Janardhan Banothu
Published: 202610.1016/j.bioorg.2026.109511
Abstract
The development of new antitubercular drugs is critically hindered by the persistent and adaptive nature of Mycobacterium tuberculosis (Mtb), underscoring an urgent need for innovative therapeutic strategies. In this work, a series of structurally va…
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