Bioorganic chemistry
Design, synthesis, and biological evaluation of hydrophobic-tagged poly (ADP-ribose) polymerase 1 (PARP1) degraders.
Jiaqian Li, Yang Cui, Mengyu Xiong, Liying Zhang, Shuo Mu, Ziqi He, Hongcheng Zhu, Kaiyin Yang, Qidi Zhong
Published: 202610.1016/j.bioorg.2026.109507
Abstract
Given its critical role in mediating the DNA damage response and repair, Poly (ADP-ribose) polymerase-1 (PARP1) has been established as a significant therapeutic target for cancer and a multitude of other human diseases. In this study, a novel series…
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