Bioorganic chemistry
Engineered N-terminal modified α/β-hybrid peptides with enhanced selectivity and stability: Multi-target antibacterials for combating MRSA.
Jyoti Kumari, Aminur Rahman Sarkar, Beenish Rashid, Arti Rathore, Shifa Firdous, Rubina Chowdhary, Biplab Sarkar, Rakshit Manhas, Rajkishor Rai, Avisek Mahapa
Published: 202610.1016/j.bioorg.2026.109495
Abstract
Cytotoxicity, hemolytic effects, poor enzymatic stability and high manufacturing costs are the major challenges associated with the clinical development of antibacterial peptides. We designed and synthesized a new series of short cationic α/β-hybrid…
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