Bioorganic chemistry
Targeting the phosphoinositide 3-kinase signaling pathway and epidermal growth factor receptor: The potential of dimethylcardamonin-derived amino acids in triple-negative breast cancer therapy.
Pornthip Chawapun, Nopawit Khamto, Yazdaniyar Fajri Halimi, Kraikrit Utama, Sadanon Siriphong, Atchara Janthong, Nathupakorn Dechsupa, Jiraporn Kantapan, Nawee Kungwan, Thanyada Rungrotmongkol, Puttinan Meepowpan, Padchanee Sangthong
Published: 202610.1016/j.bioorg.2026.109483
Abstract
Targeting the phosphoinositide 3-kinase (PI3K) signaling pathway, along with the epidermal growth factor receptor (EGFR), presents a promising strategy for breast cancer treatment. Here, dimethylcardamonin (DMC, 1), isolated from Syzygium nervosum se…
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