Bioorganic chemistry
Design, synthesis, and antidiabetic evaluation of triazolopyrimidine thioacetamides as potent and selective α-glucosidase inhibitors.
Fariba Peytam, Maryam Norouzbahari, Bahareh Bayati, Hayrettin Ozan Gülcan, Vahid Sheibani, Maliheh Barazandeh Tehrani, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Fahimeh Ghasemi, Mohammadreza Torabi, Meghdad Payab, Fatemeh Safari, Loghman Firoozpour, Alireza Foroumadi
Published: 202610.1016/j.bioorg.2026.109482
Abstract
Diabetes mellitus is a global health challenge characterized by chronic hyperglycemia. α-Glucosidase inhibitors, like acarbose, are pivotal in managing postprandial blood glucose levels but are often associated with gastrointestinal side effects. Thi…
Preview only. Read the full abstract at the source