Bioorganic chemistry
Design and evaluation of novel pyrimidine-based nucleoside analogs as antivirals: Identification of MCH-1623 as a potent broad-Spectrum antiviral candidate.
Xu Yan, Hao Sun, Chunhuan Mo, Ling Ma, Chunbin Hu, Zhenyu Zhong, Yi Su, Lehua Yin, Jinyan Zhang, Jia Chen, Yaohui Liu, Xia Han, Yan Liu, Jinghua Xu, Shan Cen
Published: 202610.1016/j.bioorg.2026.109472
Abstract
Expanding the chemical diversity of nucleosides is a vital challenge in developing antivirals. It is suggested that their volume restricts viral RdRP recognition of bases. Since the volume of substituted pyrimidines is smaller than that of purines, t…
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