Bioorganic chemistry
A dual-targeting antimicrobial agent: Discovery and mechanism of action of a novel 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine compound.
Weiqing He, Yajing Tian, Ke Li, Jinman Che, Muchun Cheng, Jieya Shang, Yi Hua, Qiang Fu, Kunhao Qin, Yuanying Jiang, Xianqing Deng, Xunli Xiao, Mingxia Song
Published: 202610.1016/j.bioorg.2026.109471
Abstract
Drug-resistant pathogens pose severe threats to public health, driving the need for new antibacterial agents. Herein, we report the design, synthesis, and biological evaluation of a series of 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline derivatives (PQDs…
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