Bioorganic chemistryGinsenosidesPulmonary FibrosisHypoxia-Inducible Factor 1alpha SubunitEpithelial-Mesenchymal Transition
Mechanism of ginsenoside AD-1 improving pulmonary fibrosis by regulating the HIF-1α/ HSP/TGF-β1 signaling pathway and mesenchymal transition.
Maxin Ji, Yudong Zhang, Xianyi Xiao, Yunjie Ma, Xiujuan Sun, Yipeng Wang, Yiteng Ma, Yuqing Zhao, Guangyue Su
Published: 202610.1016/j.bioorg.2025.109445
Abstract
In China, approximately 450,000 cases of pneumoconiosis account for 90 % of all occupational diseases, with an annual increase that poses health threats and economic burdens worldwide. Previous research revealed that AD-1, an acidic hydrolysate deriv…
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