Bioorganic chemistry
A Phenstatin-based indole-chalcone hybrid as novel anti-inflammatory agent targeting the NLRP3 Inflammasome: Leads from computational and preclinical studies.
Rajesh Kumar Meher, Jitendra Maharana, Jeshma Kovvuri, K Nirmal Kumar, Trupti Pradhan, Vaishali Kailaje, Arvind Ingle, Subrata Sen, Madan Barkume, Meena Patkar, Anand Vaibhaw, Showkat Ahmad Mir, Arpita Ghosh, Sanjeev Kamte, Ahmed Kamal
Published: 202510.1016/j.bioorg.2025.109429
Abstract
Dysregulated activation of NLRP3 inflammasome contributes to tumor development and progression. We previously identified and characterized 9a, a phenstatin-based indole-chalcone hybrid exhibiting potent anti-oral cancer activity. This study was aimed…
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