Bioorganic chemistryBiofilmsAntifungal AgentsCandida albicansDrug DesignThiazoles
Targeting fungal biofilms: Design, synthesis and evaluation of pyrrolidino-hydrazinyl-thiazole derivatives via in vitro, transcriptomic and in silico approaches.
Mahesh N Waman, Sanyukta Salve, Rajesh B Patil, Vishal S Waghchaure, Shaikh Yahya, Farukh S Sayyad, Ashishkumar P Katariya, Dinesh Rathod, Jaiprakash N Sangshetti, Rajendra H Patil, Satish U Deshmukh
Published: 202610.1016/j.bioorg.2025.109428
Abstract
The increase in the drug resistance in fungal infections, particularly those involving biofilm-forming species like Candida albicans, presents a global challenge to public health. The biofilm forming abilities of C. albicans contributes to high rates…
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