Bioorganic chemistryFerroptosisHumansPPAR gammaKruppel-Like Factor 4STAT6 Transcription Factor
Macelignan targets SLC7A11 to induce ferroptosis and modulate macrophage polarization via STAT6/PPAR-γ/KLF4 signaling.
Dianyu Sun, Xingzhe Liu, Chuwen Mao, Fangxuan Zhao, Wenjing Fan, Chenghao Li, Yanhua Xuan
Published: 202610.1016/j.bioorg.2025.109422
Abstract
Tumor-associated macrophages (TAMs) with an M2-like phenotype are key contributors to the development and immune escape of hepatocellular carcinoma (HCC). We show that the natural product macelignan (mace) reshapes macrophage polarization through a f…
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