Bioorganic chemistryAzithromycinAnti-Bacterial AgentsHeterocyclic CompoundsMicrobial Sensitivity TestsStructure-Activity Relationship
4″-modified azithromycin derivatives bearing nitrogen-containing heterocycles with dual inhibitory activity.
Maksim M Martynov, Inna A Volynkina, Natalia E Grammatikova, Maksim A Kryakvin, Nikolai D Dagaev, Anastasiia O Karakchieva, Olga A Dontsova, George V Zatonsky, Alexander S Tikhomirov, Andrey E Shchekotikhin
Published: 202610.1016/j.bioorg.2025.109396
Abstract
The escalating threat of antimicrobial resistance demands innovative strategies to revitalize existing antibiotic classes. Here, we address the challenge of macrolide resistance by designing and synthesizing a series of novel azithromycin derivatives…
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