Bioorganic chemistryHumansLightDrug DesignNeoplasmsProteolysis
Advances in light-controllable PROTACs: Design strategies, therapeutic applications and current challenges.
Ji Wu, Zi-Yue Wang, Shi-Xuan Tan, Ting-Yu Li, Bing-Bing Chen, Qi-Qi Chen, Hao Li, Jin-Bo Niu, Xiang-Jing Fu, Jian Song, Sai-Yang Zhang
Published: 202610.1016/j.bioorg.2025.109380
Abstract
Light-controllable protein degradation-targeting chimeras (Light-controllable PROTACs) have emerged as a novel strategy for spatiotemporal regulation of protein degradation, with significant advances in molecular design and therapeutic applications i…
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