Bioorganic chemistryHumansEstrogen Receptor betaAniline CompoundsCarcinomaNon-Small-Cell Lung
Targeted degradation of estrogen receptor β to overcome Osimertinib resistance in non-small cell lung carcinoma.
Yunchong Meng, Xiaofei Deng, Baohua Xie, Wei Lin, Na Wang, Xiaojun Wang, Shihao Wu, Chune Dong, Yongde Liao, Hai-Bing Zhou
Published: 202610.1016/j.bioorg.2025.109374
Abstract
Osimertinib resistance remains a major challenge in advanced non-small cell lung cancer (NSCLC) patients. Estrogen receptor β (ERβ) has been identified as a vital promoter in the emergence of Osimertinib resistance in NSCLC cells, however, the mechan…
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