Bioorganic chemistryFerroptosisHumansLactonesLiver NeoplasmsHeme Oxygenase-1
Dehydrocostus lactone promotes ferroptosis by regulating the HMOX1/CDK1 axis during liver cancer treatment.
Kui Long, Zhitian Shi, Weiran Liao, Yutao He, Lixin Liu, Lin Wang
Published: 202610.1016/j.bioorg.2025.109349
Abstract
Dehydrocostus lactone (Dehy) is the main component of Saussurea lappa and has been shown to have anti-inflammatory and anti-cancer properties. This study aimed to explore the specific mechanism of action of Dehy in liver cancer. Dehy can effectively…
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