Bioorganic chemistrySulfonesPeptidomimeticsHumansCysteine Proteinase InhibitorsStructure-Activity Relationship
Review of peptidomimetic vinyl sulfones targeting cysteine proteases and proteasomes.
Reza Ahmadi, Saeed Emami
Published: 202610.1016/j.bioorg.2025.109323
Abstract
Peptidyl vinyl sulfones (PVSs) are a prominent class of irreversible covalent inhibitors of cysteine proteases and proteasomes which are essential enzymes for maintaining proteostasis and regulating cellular processes. Structurally, they are characte…
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