Bioorganic chemistryHumansRatsAnimals3-Oxo-5-alpha-Steroid 4-DehydrogenaseStructure-Activity Relationship
Biphasic inhibition of human and rat steroid 5α-reductase 1 for Neurosteroid synthesis by mid-chain Dialkyldimethylammonium compounds (C8-C14): Kinetic, SPR binding, computational insights, and implications for environmental toxicology.
Hao Lin, Yinghao Huang, Shaowei Wang, Chentao Ding, Longsheng Xu, Ren-Shan Ge, Ming Yao
Published: 202610.1016/j.bioorg.2025.109321
Abstract
Dialkyldimethylammonium compounds (DDAs) are quaternary ammonium compounds widely used as disinfectants and industrial materials. However, their effects and mechanisms on neurosteroid and androgen synthesis disruption remain unclear. This study eluci…
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