Bioorganic chemistryHumansStructure-Activity RelationshipQuinolinesCell ProliferationAntineoplastic Agents
Quinolinyl-appended chalcones as promising antiproliferative and trypanocidal agents: Synthesis, biological profiling, and further transformation into novel benzo[f]pyrazolo[5,1-a][2,7]naphthyridine and quinoline-pyrido[2,3-d]pyrimidin-2,4-dione hybrids.
Diego Rodríguez, Elizabeth Gómez, Mauricio Moncada-Basualto, Esteban Rocha-Valderrama, Elena Stashenko, Justo Cobo, Alirio Palma
Published: 202610.1016/j.bioorg.2025.109306
Abstract
An efficient synthetic methodology has been developed for the transformation of readily available quinolinyl-chalcones 2 and their 3-acetylquinoline 1 precursors into novel benzo[f]pyrazolo[5,1-a][2,7]naphthyridine 3 and quinoline-pyrido[2,3-d]pyrimi…
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