Bioorganic chemistryDecarboxylationCarbon DioxideCarboxy-LyasesMolecular StructureKinetics
Transient adducts of CO2 with nucleophiles enhance rates of enzymic decarboxylation.
Jerry Augustine, Marc Alexander Zambri, Ronald Kluger
Published: 202610.1016/j.bioorg.2025.109299
Abstract
Benzoylformate decarboxylase (BFDC) forms an adduct of thiamin diphosphate (ThDP), and benzoylformate, following the mechanism proposed by Breslow for related enzymes. Structural studies by Hasson and coworkers revealed inactivation of the enzyme by…
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