Bioorganic chemistryTriple Negative Breast NeoplasmsHumansAntineoplastic AgentsDrug Screening AssaysAntitumor
Synthesis of self-immolative NO donor-aurovertin B conjugate as potent anti-triple negative breast cancer agents.
Yi-Li Chen, Xun Zhou, Ting-Zhu Ye, Yuan Peng, Zha-Jun Zhan, Luo Fang, Lie-Feng Ma
Published: 202510.1016/j.bioorg.2025.109276
Abstract
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with a poor prognosis and limited response to existing therapies, posing a serious challenge to global women's health. Aurovertin B (AurB), a microbial-derived ATP s…
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