Bioorganic chemistrySTAT3 Transcription FactorHumansAnimalsAntineoplastic AgentsNaphthoquinones
Discovery of a novel diphenyl piperidinone-naphthoquinone STAT3 inhibitor as chemoimmunotherapeutic agent.
Yi-Gui Qin, Zhi-Chen Mao, Lei Chen, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Published: 202510.1016/j.bioorg.2025.109274
Abstract
A series of novel diarylpiperidinone-naphthoquinone hybrids were designed and synthesized. Among these, compound 8d emerged as a potent inhibitor targeting the STAT3 SH2 domain. In vitro evaluation using Cell Counting Kit-8 (CCK-8) assay demonstrated…
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