Bioorganic chemistryHumansCholinesterase InhibitorsMolecular Docking SimulationAcetylcholinesteraseStructure-Activity Relationship
Dual targeting of neuroblastoma and cholinesterase by morpholino/pyrrolidino-sulfonyl-indole thiosemicarbazones: Synthesis, characterization, enzyme inhibition, cytotoxicity, docking and dynamics studies.
Zahra Batool, Gülbahar Özge Alim Toraman, Furkan Çakır, Gülaçtı Topçu, Parham Taslimi, Rima D Alharthy, Ajmal Khan, Ahmed Al-Harrasi, Zahid Shafiq, Halil Şenol
Published: 202510.1016/j.bioorg.2025.109252
Abstract
In this study, twenty novel morpholino/pyrrolidino-sulfonyl-indole thiosemicarbazone derivatives (6a-j and 7a-j) were synthesized and tested for cholinesterase inhibition and anticancer activity. Compounds 6h and 7h stood out as the most potent inhib…
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