Bioorganic chemistryLysosomesHumansProteolysisDrug DesignProteins
Lysosome-Targeting Chimeras: Design, Mechanisms, and Degradation of "Rogue" Proteins.
Muneeb Ur Rehman, Xinxi Wu, Qun Chen, Ziwei Liu, Sihui Long
Published: 202510.1016/j.bioorg.2025.109249
Abstract
Inhibition of proteins has been a key approach in drug development for various diseases. Many therapeutic approaches have been developed till date to effectively disrupt disease-associated proteins. However, challenges such as associated side effects…
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