Bioorganic chemistryBiological ProductsHumansUbiquitin-Protein LigasesProteomicsDrug Discovery
Diversified applications and research progress of plant-derived natural products in PROTAC technology.
Mingyu Ma, Jie Cheng, Jie Wang, Peiyue Cao, Yan Wei, Qian Jiang, Mengjia Yu, Yi Bi
Published: 202510.1016/j.bioorg.2025.109241
Abstract
This review systematically summarizes the various applications of plant-derived natural products in PROTAC technology, specifically as E3 ligase ligands, protein-of-interest ligands, and facilitators for natural product target identification. By harn…
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