Bioorganic chemistryfms-Like Tyrosine Kinase 3HumansProtein Kinase InhibitorsStructure-Activity RelationshipPyridines
Identification of 2,4-disubstitued pyridine derivatives as potent FMS-like tyrosine receptor kinase 3 (FLT3) inhibitors.
Zhongyuan Wang, Xinfu Liu, Youli Hou, Dongdong Cao, Shiyu Hu, Lihong He, Yiwei Zhang, Dongsheng Zhao, Rui Chen, Wenzhang Chen, Aihong Li, Weiwei Ouyang, Weike Liao
Published: 202510.1016/j.bioorg.2025.109229
Abstract
Accumulating evidence has shown that FMS-like tyrosine receptor kinase 3 (FLT3) activity plays a critical role in a substantial proportion of patients diagnosed with acute myeloid leukemia (AML), making it a potential molecular target for therapeutic…
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