Bioorganic chemistryHumansMaleProstatic NeoplasmsPTEN PhosphohydrolaseAntineoplastic Agents
Inhibition of nuclear ROCK2 by a novel thiourea derivative induces potent antitumor effects through PTEN/FOXO1 pathway restoration in prostate cancer.
Jiwoo Lee, Kalpana Ghimire, Dongchul Lim, Kiran Yadav, Prakash Chaudhary, Hyunjin Kim, Hee Dong Park, Jung-Ae Kim, Byeong-Seon Jeong
Published: 202510.1016/j.bioorg.2025.109211
Abstract
Aberrant activation of the PI3K/Akt signaling pathway and frequent silencing of the tumor suppressor PTEN are central drivers of prostate cancer progression and therapeutic resistance. Addressing this dual dysregulation, we identified compound 25, a…
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