Bioorganic chemistryHumansAntigensNeoplasmPositron-Emission TomographyLung Neoplasms
De novo discovery and preclinical evaluation of a novel peptide radiotracer for PET imaging of TROP-2 in non-small cell lung cancer.
Ximiao Yu, Jing Fang, Yan Xue, Zhihong Huang, Jiehong Wang, Xue Zhu, Xun Wang, Tangfeng Lv, Ke Wang
Published: 202510.1016/j.bioorg.2025.109204
Abstract
Trophoblast cell surface antigen 2 (TROP-2) is frequently overexpressed in non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma (LUAD), making it a promising target for the diagnosis and treatment of this malignancy. In this study,…
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