Bioorganic chemistryBenzamidesCyclopropanesCyclic Nucleotide PhosphodiesterasesType 4Humans
Design and development of potent roflumilast analogues targeting PDE-4B: selectivity and pharmacokinetic insights.
Ahmed M Moussa, Heba Abdelrasheed Allam, Ahmed A Al-Karmalawy, Abdelrahman K Salem, Radwan Alnajjar, Sally T Mahmoud, Marwa A Fouad, Mohamed K El-Ashrey
Published: 202510.1016/j.bioorg.2025.109201
Abstract
Phosphodiesterase-4B (PDE4B), a key regulator of intracellular cAMP degradation, has emerged as a compelling therapeutic target due to its involvement in various diseases, such as inflammation, COPD, schizophrenia, cancer, and cardiac disorders. Two…
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