Bioorganic chemistryReceptor-Interacting Protein Serine-Threonine KinasesHumansMolecular StructurePhotoaffinity LabelsNeovascularization
Identification of RIPK1 as a novel target for angiogenesis regulation based on ABT-869 conjugated photoaffinity probes.
Yanchen Li, Tingting Liu, Weihua Cheng, Lifeng Zhao, Yangchao Wei, Jin Wang, Junyu Zhang, Jie Zhang
Published: 202510.1016/j.bioorg.2025.109191
Abstract
Angiogenesis plays an important role in the stages of tumor initiation, development, metastasis and invasion. Angiogenesis regulation has gradually emerged as an effective strategy for clinical anti-tumor therapy and prognosis. The discovery and conf…
Preview only. Read the full abstract at the source