Bioorganic chemistryHumansAntineoplastic AgentsStructure-Activity RelationshipDrug DesignCaspase 3
Cafeic acid benzylidene hydrazides as novel procaspase-3 activators: Rational design, synthesis, and mechanistic evaluation of antitumor efficacy.
Zhongyuan Guo, Run Wang, Qingsi Zhao, Xiaoqian Liu, Hong Yang, Yaohua Liang, Zhimin Wang, Chenxiaoning Meng
Published: 202510.1016/j.bioorg.2025.109174
Abstract
Caspase-3 is an essential intracellular protein mediating cell apoptosis and a key target in the apoptosis pathway of cancer cell. Activating its existing inactive proenzyme, Procaspase-3, induces apoptosis in various tumor cells and has emerged as a…
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