Bioorganic chemistryHumansErbB ReceptorsSulfonamidesProtein Kinase InhibitorsLung Neoplasms
Novel pyrrole-sulfonamide derivatives as EGFR inhibitors and radiosensitizers in lung cancer.
Mostafa G M El-Gazzar, Sally S Zahran, Mostafa M Ghorab, Marwa G El-Gazzar
Published: 202510.1016/j.bioorg.2025.109173
Abstract
Molecular hybridization strategy is of significant importance in drug discovery. This study describes the design and synthesis of sulfonamide and pyrrole hybrid in a single design as a potential epidermal growth factor enzyme (EGFR) inhibitors agains…
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