Bioorganic chemistryHumansAntineoplastic AgentsProtein Kinase InhibitorsErbB ReceptorsVascular Endothelial Growth Factor Receptor-2
Design, synthesis, and antitumor evaluation of new pyridazinone scaffolds as dual EGFR/VEGFR-2 kinase inhibitors and apoptotic cells inducers.
Sara Y Ewieda, Eman M Ahmed, Nirvana A Gohar, Shaymaa G Ibrahim, Marwa A Essa, Mohamed T M Nemr
Published: 202510.1016/j.bioorg.2025.109157
Abstract
Three new sets of pyridazinone 5a-h, 6a,b, and 7a,b were designed and synthesized as potent antineoplastic agents against colon (HCT116), liver (HepG2), and breast (MCF-7) cancer cell lines. Compounds 5b,f and 7a displayed excellent cytotoxic activit…
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