Bioorganic chemistryHumansG-QuadruplexesTriple Negative Breast NeoplasmsAntineoplastic AgentsLigands
Exploration of chromenone-based ligands as DNA G-quadruplex targets in triple-negative breast cancer.
Phooi Yan Mock, Eng Wee Chua, Aaron Stevens, Fatimah Salim, Kok Wai Lam
Published: 202510.1016/j.bioorg.2025.109150
Abstract
Triple-negative breast cancer (TNBC) is a highly aggressive and metastatic subtype of breast cancer with limited treatment options and poor prognosis. Therefore, there is a pressing need for novel anti-cancer treatments for TNBC. G-quadruplexes (G4s)…
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