Bioorganic chemistryHumansApoptosisTriple Negative Breast NeoplasmsAntineoplastic AgentsStructure-Activity Relationship
Synthesis and evaluation of 8-(benzyloxy)-5,7-dibromo-2-methylquinoline derivatives as inducers of apoptosis in triple-negative breast cancer MDA-MB-468 cells via MKK7-JNK pathway activation.
Liang Ma, Shizhun Zhang, Xiuping Mao, Zhigang Lu, Zixuan Tong, Junhui Guo, Junfeng Hu, Kaili Chang, Zi Liu, Guozheng Huang
Published: 202510.1016/j.bioorg.2025.109117
Abstract
To discover novel anti-cancer agents, a total of twenty derivatives of 8-hydroxyquinoline were synthesized by alkylation and benzylation of 8-hydroxyl-5,7-dibromo-2-methylquinoline. The anti-cancer activity of these compounds against triple-negative…
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