Bioorganic chemistryHumansNuclear Receptor Subfamily 4Group AMember 1Drug Design
Design, synthesis, and evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as anti-HCC agents targeting Nur77.
Shengwei Hu, Xiaodan Li, Mingyue Yu, Haofan Zhang, Xiang Wang, Chen Qi, Shiyan Huang, Ziyi Xu, Hongyu Hu, Siming Chen, Meijuan Fang, Jinzhang Zeng
Published: 202510.1016/j.bioorg.2025.109113
Abstract
Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited treatment options for advanced-stage patients. The orphan nuclear receptor Nur77 has emerged as a promising therapeutic target in HCC. Leveraging a molecular hybridi…
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