Bioorganic chemistryHumansVascular Endothelial Growth Factor Receptor-2ErbB ReceptorsAntineoplastic AgentsDrug Screening Assays
Design, synthesis and biological evaluation of novel pyrazoline derivatives as dual EGFR/VEGFR-2 inhibitors for targeted cancer therapy.
Michael M Sawiris, Omneya M Khalil, Peter A Halim, Marwa S A Hassan
Published: 202510.1016/j.bioorg.2025.109075
Abstract
Three series of pyrazoline compounds (3a-f, 4a-f and 5a-f) were designed and synthesized as antiproliferative agents and potential dual EGFR/VEGFR-2 inhibitors for targeted cancer therapy. All the synthesized compounds were screened by National Cance…
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